epigenetic alterations and their impact on assisted reproduction technology outcomes

Epigenetic Alterations and their Impact on Assisted Reproduction Technology Outcomes

It is already three decades since the birth of the first “test-tube baby” in 1978 and such methods have found their due place in most countries. In Denmark alone, more than 6% of children are born through assisted reproduction technologies (ARTs) (1). In the United States, more than 50,000 babies are born through IVF annually and there are more than 4 million people born through such methods ar...

Epigenetic Alterations in Density Selected Human Spermatozoa for Assisted Reproduction.

Epidemiological evidence indicates that assisted reproductive technologies (ART) may be associated with several epigenetic diseases such as Beckwith-Wiedemann syndrome (BWS) or Silver-Russell syndrome (SRS). Selection of sperm by density-gradients in ART has improved DNA integrity and sperm quality; however, epigenetic alterations associated with this approach are largely unknown. In the presen...

Microbial colonization of follicular fluid: alterations in cytokine expression and adverse assisted reproduction technology outcomes.

BACKGROUND Previous studies have measured cytokines expressed within follicular fluid and compared the profiles with the aetiology of infertility and/or successful or unsuccessful assisted reproduction technology (ART) outcomes. METHODS In this study, 71 paired follicular fluid and vaginal secretions collected from ART patients were cultured to detect microorganisms and tested for the presenc...

O-30: Impact of Environment Tobacco Smoke Exposure on Oxidative Stress in Antral Follicle and Assisted Reproduction Outcomes

Background: Cigarette smoke contains many oxidants and may alter the human reproduction by inducing oxidative stress (OS) in both active and passive smokers. This study was designed to evaluation the effect of environment tobacco smoke (ETS) exposure on oxidative stress in follicular follicle and assisted reproduction outcomes. Materials and Methods: A prospective study was carried out on 236 i...

Assisted reproduction treatment and epigenetic inheritance

BACKGROUND The subject of epigenetic risk of assisted reproduction treatment (ART), initiated by reports on an increase of children with the Beckwith-Wiedemann imprinting disorder, is very topical. Hence, there is a growing literature, including mouse studies. METHODS In order to gain information on transgenerational epigenetic inheritance and epigenetic effects induced by ART, literature dat...

How Can Personalized Medicine Improve Assisted Reproduction Technology Outcomes?